Useful Tips

Retin A


Retin-A is available in three dosage forms:

  • Gel 0.1%, containing 0.025% of the active substance - tretinoin (retinoic acid),
  • 0.05% gel containing 0.1% tretinoin,
  • A solution containing 0.1% tretinoin.

Pharmacodynamics and pharmacokinetics

Retin A is retinoid, similar in structure to vitamin A. When used internally, it inhibits the growth and differentiation of altered blood cells, including myeloid leukemia cells. External use allows enhancing cell proliferation in the papillary skin layer, reducing the adhesion of those cells that are involved in the formation of acne.

Treatment open eels leads to smooth skin without inflammation. Closed acne when treated with Retin A, they become open or papuleswhich, after removing the keratin plug, heal without scars. The cream also reduces the risk of new acne.

Tretinoin, which is a natural metabolite of retinol, is absorbed from the digestive tract. Its plasma concentration after 7-12 hours returns to its original endogenous level. A high level of binding to plasma proteins does not cumulate. About 60% is excreted in the urine of tretinoin, the rest with feces.

Indications for use

  • vulgar acne (with education papule, comedones or pustules),
  • Favre-Rakusho disease,
  • drain eels.

Ingestion is prescribed when acute promyelocytic leukemia.

What kind of cream

For the treatment of acne, a drug for external use of Retin A cream is prescribed.

Instructions for use include the drug in the group of dermatotropic.

In cosmetology, the drug is used to rejuvenate the skin and eliminate small wrinkles.

The cream is dense thick, the smell is unstable flower. There are 3 therapeutic concentrations of 0.025%, 0.05%, 0.01%.

Retin A is nothing more than a natural metabolite of retinol, a form of vitamin A.

It is made in Thailand.


Use the drug inside is contraindicated in lactation, pregnancysensitivity to tretinoin, cutaneous epithelium in the anamnesis.

External use is prohibited in the presence of wounds, acute inflammatory skin lesions, burns.

Side effects

Taking the medicine may cause the following effects:

  • fever, pulmonary infiltrate, dyspnea, arterial hypotensionrespiratory distress syndrome, pleural effusion, liver failure, dyspnea, hyperleukocytosis, renal failure,
  • celluliterash, mucosal dryness, sweating, cheilitis, xeroderma, erythema, alopecia, xerophthalmia, exfoliative dermatitisitching
  • nausea, stomatitis, diarrheavomiting, dry mouth, abdominal pain, constipationincreased activity of liver transaminases,
  • depressionimpaired consciousness, impaired vision, hearing, increased intracranial pressure, anxiety, dizziness,
  • weight change, increased cholesterol, plasma triglycerides,
  • stridorous breathing pharyngitis, pleural effusion, shortness of breath, swelling of the nasal mucosa, wheezing in the lungs,
  • arrhythmias,
  • pain in bones, joints, muscles,
  • increased bleeding
  • chillsweakness fever, drowsiness, pain in the back, chest.

With external use, redness, peeling of the skin, swelling, burning, photosensitization, the appearance of a crust, blisters.


Pharmacokinetic parameters may change with the simultaneous use of tretinoin with drugs that affect the enzymes of the CYP450 system.

Contraceptive effect progesterone decreases due to the use of tretinoin.

Combined use with tetracyclines may lead to increased pressure inside the skull.

Hypervitaminosis may be observed with vitamin A.

special instructions

Only a doctor who has experience in the treatment of cancer and hematological diseases can prescribe Retin A inside.

Chemotherapy in an adequate dose is prescribed with a strong increase in white blood cells to prevent retinoic acid syndrome. Dexamethasone appointed when the first symptoms of this syndrome occur.

Do not allow the cream to get into the mouth, eyes, mucous membrane, if it gets into it, rinse thoroughly with water.

During the first week of the course, acne may intensify.

Avoid exposure to the sun during treatment. You can start the course after lowering your tan.

Should not be used tretinoinwith those drugs that cause skin desquamation. Also, do not use hygiene and cosmetic products during treatment that cause skin irritation and dryness.

The analogues of this drug include locacid, vesanoid and tretinoin.

During pregnancy and lactation

If you need to take the drug inside, you should temporarily stop breast-feeding.

Retin A is contraindicated in pregnant women.

One month before the start of the course, during the course and one month after discontinuation, women should use effective contraceptives. They begin to apply on the 2nd or 3rd day of the menstrual cycle. It is recommended that laboratory tests confirm the absence of pregnancy before starting therapy at least 2 weeks in advance. During treatment, tests should be performed every month.

Rentin A: Application

Internal use of Retin A is carried out only as prescribed by the oncologist or gemologist (specialist in blood diseases). The dose is calculated in milligrams per unit area of ​​the patient’s body. When taken orally, the drug can cause complications in the form of the so-called retinoic acid syndrome - the patient begins to have shortness of breath, fever, respiratory rhythm disturbance, the appearance of infiltrate in the lungs, liver and kidney failure, and acute leukocytosis. When the first symptoms of retinoic acid syndrome appear, dexamethasone and other desensitizing drugs are used.

External use of the drug is possible without a doctor’s prescription, however, it is advisable to first communicate with a specialist and observe the reaction of the body the first time after the start of the drug. All Retin A preparations are contraindicated during pregnancy, it is mandatory to undergo a pregnancy test before taking the tablets, and women are also advised to use contraceptives during the treatment with Retin A. During the treatment with the drug during lactation, breastfeeding should be stopped.

Retin A is not used if the patient has skin diseases, as well as if he has a family predisposition to such diseases. The drug is contraindicated in skin eczema, acute inflammation of the skin, wounds, burns, for children under 12 years of age and in the presence of individual intolerance. Before starting the use of the drug, an allegrotest is mandatory - it is applied with a thin layer on the inside of the elbow and if an allergic reaction to topical application does not develop within 15 minutes, the drug is allowed to be used for this patient.

The drug also has genetic contraindications. For example, most researchers insist that before using it, it is necessary to conduct a cytological examination of the body to find out if the patient is a carrier of the translocation t (15, 17) and / or the PML / RAR alpha gene. With positive cytology results, Retin A cannot be used to treat this patient.

While taking the medicine, you can not be in the sun for a long time, since the drug enhances photosensitivity. If you have tanned skin, you will have to postpone the drug for one to two weeks until the fresh tan comes off. It is optimal to be treated with Retin A in autumn and winter - at this time there is less chance to encounter factors causing complications. You can not take vitamin A preparations at the same time as Retin A - this can cause hypervitaminosis. When combined with antibiotics of the tetracycline series, a sharp increase in intracranial pressure can be observed. It is not recommended to combine Retin A with cosmetics that dry or irritate the skin, as well as containing alcohol.

The following dosage forms of Retin A are applied externally - an ointment based on water and oil, an aqueous solution and a gel. The scope of their application is the treatment of vulgar acne, including comedones, papules, pustules, drain acne (the so-called grouped acne with merged ducts), flat warts, follicular keratosis (keratinization of the mouth of hair follicles, which are clogged by keratinized cells, resulting in the formation of rough, itchy areas on the shoulders and hips). Also, Retin A cream and gel are used to treat hyperpigmentation, to eliminate bumps and wrinkles caused by sun damage to the skin.

How to use Rentin A

The skin must be prepared for application Retin A - thoroughly wash and dry. Cream, gel or lotion is applied with fingers or a cotton swab to the affected areas in a minimal amount, with a thin layer. It is best to carry out this procedure at night, especially since the drug is usually used once a day. At first, a burning sensation or a sensation of warmth may appear at the application site. The skin may turn slightly red - this effect will be observed during the first five weeks of using the product. In the event that too much burning appears during application, the frequency of use of the drug is temporarily reduced and used once every two or three days. The first two weeks most often occurs exacerbation of acne. This is due to the fact that all deep eels begin to ripen en masse and go outside. The optimal duration of Retin A treatment is 8-12 weeks, but the course can last up to three months. After completing the course, the skin must be allowed to rest for six months. It may take 4 to 24 weeks to treat sun damage to the skin. Therefore, such treatment will require perseverance and patience. However, the results of those who have tried this remedy are mostly positive.

Like all oil-soluble vitamins and their derivatives, Retin A should be stored in a dark, cool place, since under the influence of sunlight it is decomposable and also combustible, so its storage temperature should not exceed 30 degrees Celsius. The medicine must be kept out of the reach of children. Retin A tablets can be stored for three years, the shelf life of ointments, solutions and gels in the closed state is three years.

Rentin A: Price

Prices for Retin preparations And you cannot classify them among the inexpensive ones - a 20 gram tube of gel or cream will cost you about 45 euros. Retin A water solution is slightly cheaper - 40 euros per 50 ml bottle. The search for the opportunity to purchase the drug showed that Retin A is not available in all pharmacies. All tretinoin preparations are produced by foreign pharmaceutical companies (Jansens, Belgium, Obadzhi Medical, USA and others), there are currently no domestic analogues in the pharmaceutical market. Therefore, if you decide to try to cope with acne with the help of Retin A, look for a remedy in online pharmacies on order.

Rentin A: Reviews

Analysis of reviews on Internet resources in general allows recommending Retin A for the treatment of acne. Only those who were expecting a miracle and instant effect from the drug were disappointed. Most of those who have tried Retin A for the treatment of various types of acne and keratosis note a period of sharp exacerbation of the disease, especially in the first or second week of use. Among the negative reviews, there are also those that are associated with improper use of the drug, especially in the summer, or associated with improper combination of the drug with other medicinal and cosmetic products. It should also be noted the existing difficulties with the acquisition of Retin A in Russia and Ukraine, due to the fact that it is not available in all pharmacies and can be purchased only on order.

pharmachologic effect

According to the instructions Retin-A accelerates the maturation of skin cells lining the hatching parts of the hair follicles. Accumulating, these cells block the exit of the bulb and block the outflow of secretions of the gland, resulting in an inflammatory process on the skin. The use of Retin-A reduces the adherence of these cells to each other and accelerates their maturation.

Pharmacological properties

The drug belongs to dermatotropic drugs.

The action of the active substance:

  • stimulates collagen production,
  • exfoliates dead particles of the upper layer of the epidermis,
  • slows down the aging process
  • improves blood circulation,
  • normalizes the production of sebum,
  • retains moisture in the dermis,
  • softens sebaceous plugs,
  • relieves local inflammation,
  • acts in the deep layers of the epidermis and subcutaneous tissue,
  • prevents the formation of comedones,
  • eliminates age spots.

Dosage and administration

The product is applied once a day at bedtime after washing with gentle means. The duration of the course is 12 weeks.

There are various treatment regimens that are selected based on the individual characteristics of the patient. Start with a minimum therapeutic concentration of 0.025%.

Classic application scheme:

  • week No. 1-No. 2 - 1 day after 3,
  • №3 — ½,
  • week No. 4 - 1/1,
  • fifth week - every day,
  • week No. 6 - increase the concentration of the drug and use alternately means with different tretinoin contents.

If necessary, adjust the scheme.

In childhood, during pregnancy and HB

The tool is not intended for the treatment of children under 18 years of age.

Retin A is strictly contraindicated for use during pregnancy and breastfeeding. Before starting therapy, women of reproductive age should be absolutely sure that they are not pregnant.

During treatment and the next 12 months, it is necessary to protect against conception.

Side effects

Retin A refers to drugs with a number of side effects from all systems and organs.

Side effects are manifested due to the penetration of a substance into the systemic circulation in violation of the rules for using the drug.

The most likely violations are characteristic for vitamin A hypervitaminosis:

  • impaired liver function,
  • acidosis,
  • nausea,
  • vomiting
  • upset stool
  • dyspnea,
  • respiratory failure.

On the part of the hematopoietic system and cardiovascular - inflammation of the veins, swelling of the limbs, lowering or increasing blood pressure.

Digestive disorders - abdominal pain, decreased appetite, nausea, upset stool, impaired liver function.

Side effects of the nervous system:

  • dizziness,
  • depressed depressed mood
  • headache,
  • fatigue,
  • weakness,
  • agitation or apathy,
  • cramps
  • trembling in the limbs
  • hallucinations and confusion.

On the part of the kidneys - violation of urination, organ failure.

Respiratory system - shortness of breath, pulmonary edema, pleurisy, bronchitis and bronchial asthma.

Skin and mucous membranes - stomatitis, inflammation of the skin of the lips, swelling of the face and eyelids, itching, rash, peeling, contact dermatitis, serous.

Reported side effects are rare. In almost all cases of Retin A cream, acne is intensified. Without exception, the use of the product causes an increase in sensitivity to sunlight.

Dosing Retin-A

According to the instructions Retin-A is intended for external use. As a rule, the drug is applied once a day to the washed, dry surface of the damaged skin area.

When applying Retin-A solution, a cotton swab should be used.

After applying the drug, a short burning sensation on the skin or a feeling of warmth may occur. Slight redness on the skin can occur up to the fifth week of therapy. In the case of a strong burning sensation, it is necessary to increase the interval between application of the drug. During the first week of treatment, the appearance of acne may increase, which is associated with the effect of the drug on acne, located deep inside, which were not previously visible.

The best therapeutic effect from the use of Retin-A according to reviews is achieved after 8-12 weeks of treatment.

Storage conditions

The drug is stored in a cool, dry place for no longer than 36 months.

Information about the drug is generalized, provided for informational purposes and does not replace the official instructions. Self-medication is dangerous to health!

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